THE UBIQUITIN-SPECIFIC PROTEASE 8 ANTAGONIZES MELATONIN-INDUCED ENDOCYTIC DEGRADATION OF MT1 RECEPTOR TO PROMOTE LUNG ADENOCARCINOMA GROWTH

The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth

Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior.Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well-established.However, the implications of its receptors in lung adenocarcinoma have so far remained

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On the occurrence of the fireworm Eurythoe complanata complex (Annelida, Amphinomidae) in the Mediterranean Sea with an updated revision of the alien Mediterranean amphinomids

The presence of two species within the Eurythoe complanata complex in the Mediterranean Sea is reported, as well as their geographical distributions.One species, Eurythoe laevisetis, occurs in the eastern and central Mediterranean, likely constituting the first historical introduction to the CHONDROITIN Mediterranean Sea and the other, Eurythoe com

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Blank promissory note as a security instrument for consumer credit

The paper considers the sense of using the blank promissory note as a means of securing of consumer loan, while also questioning its purpose as means of security.The initial hypothesis is the legal absurdity of the same Margarita Glasses person being a debtor under the two different legal basis -promissory note and consumer loan.The same person is

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